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The rapid and uncontrolled growth of tumors restricts oxygen availability, making inadequate blood flow, or hypoxia, a common characteristic of nearly all solid tumors [46]
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Kong C, Ni X, Wang Y, Zhang A, Zhang Y, Lin F, et al
doi: 10.3390/toxins13040252 87
We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis
