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Recently, high intracellular vitamin C was reported to prevent oxidation-induced mutations in human cells [102]

K252a (TrkB block, 0.25 mg/kg i.p.)

Furthermore, the reactivity of a thiol depends upon its pKa, as thiolates are orders of magnitude more nucleophilic than thiols [54]

The Chlamydia pneumoniae invasin protein Pmp21 recruits the EGF receptor for host cell entry

Moreover, the metabolic reprogramming in response to oncogenic mutations plays a critical role in tumorigenesis deeply altering intracellular and extracellular metabolites, and affecting gene expression, differentiation and tumour microenvironment [3]