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An increasing number of studies are showing that TNF- and IL-6 are the primary inflammatory cytokines implicated in cancer cachexia [7, 9], and these have emerged as critical factors related to the loss of muscle mass

Necroptosis In contrast to conventional necrosis, which represents unprogrammed cell death induced by cellular damage, necroptosis is an apoptosis-independent programmed form of necrosis or inflammatory cell death [205, 206]