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& Chiba, M

[20] Advanced patients may experience a partial or complete loss of the ability to use voluntary muscles

In a study carried out by Johnson et al

Portillo Journal of Physiology and Biochemistry .2025

In a recent similar study, depletion of Tfam also reduced mesoderm differentiation efficiency and the commitment of human PSCs to cell-lineages highlighting the regulatory role of mitochondria in cell-fate determination and demonstrating that any defects in the process could lead to fetal cardiac abnormalities [39]
