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A large number of studies (see e.g (316).) make use of HRV measurements in the frame of the polyvagal theory of Stephen Porges (317)
doi: 10.1016/j.freeradbiomed.2024.07.007 15 AkaikeTIdaTWeiFYNishidaMKumagaiYAlamMMet al

Temperature and pH are the primary drivers of hydrolysis rate

Frodl T, Strehl K, Carballedo A et al (2020) Aerobic exercise increases hippocampal subfield volumes in younger adults and prevents volume decline in the elderly

Any real-world decision about an investigational drug belongs to a licensed clinician , full stop
