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J Biol Chem 280:12241229

2004 Jun;14(3):283-91

Beyond its addictive properties, short-term or long-term exposure to nicotine in adults has not been established as dangerous "Electronic Cigarettes: Vulnerability of Youth"

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However, -EC does not accumulate intracellularly in most species, because GCL catalyzing -EC synthesis is a rate-limiting enzyme and synthesized -EC is immediately converted to GSH by GS (Fig
