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Notably, 4-HNE can activate the mitochondrial ROS-mediated AKT/NF-B signaling pathway and increase MMP2 production in VSMCs (123)

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Our previous study revealed significant metabolic dysregulation in PD patients, including elevated levels of neurotoxic bile acids (cholic acid and deoxycholic acid) and decreased levels of neuroprotective ursodeoxycholic acid (UDCA) and tauroursodeoxycholic acid (TUDCA)

Folic acid supplementation to prevent neural tube defects: A limited systematic review update for the U.S

doi: 10.7150/ijms.40959 [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Sopena F, Lanas A