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Indeed, the novel melanocortin candidate AP1189, currently in phase II trials, may have been discarded early during development as it does not induce cAMP, but activates ERK1/2 phosphorylation instead (176), indicating that at least when addressing the anti-fibroblast activities of MC compounds, other pathways should be considered

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Currently, therapeutic strategies rarely integrate this hostmicrobiome axis, potentially accounting for the heterogeneous clinical responses observed in trials targeting lipid pathways