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Our findings are in agreement with other recent observations using similar ligature models, which show a considerable increase of the distance between the cemento-enamel junction and the alveolar crest, regarded as a sign of alveolar bone loss (48, 52)

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Nevertheless, studies report that administering GRF(1-29) with similar modification to CJC-1295 no DAC may be safe and well tolerated for periods of 16 weeks [17]

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