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Additionally, immunomodulatory agents like tofacitinib, a JAK inhibitor, carry risks of increased susceptibility to infections, particularly in immunocompromised individuals, as well as potential cardiovascular and thromboembolic events [153]
The rupture of the physical barrier (OMM) that limits their release into the cytosol constitutes a point-of-no-return in cell death (Martinou and Green, 2001
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The house-keeping gene was -actin and the primer sequences were as follows: -actin, 5-ACCCACACTGTGCCCATCTA-3 (forward) [36], 5-TAGAGCAACATAGCACAGCTTC-3 (reverse)
