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2 Anatomy of the intervertebral disc and degeneration The intervertebral disc (IVD) is a fibrocartilaginous structure located between adjacent vertebral bodies, composed of the outer annulus fibrosus (AF), the central nucleus pulposus (NP), and the superior and inferior cartilage endplates (CEP)

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In preclinical and clinical research it has been studied for its effect on glucose-dependent insulin secretion, energy intake and body-weight regulation in metabolic models, and downstream cAMP/PKA signalling at both receptor families