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The REM cycle length changes depending on Ta with a delayed REM cycle in low Ta compared with high Ta [94], and the REM propensity has a close relationship with body temperature rhythm [95]

Wolchok JD

Traditionally, options were limited to painkillers, steroids, or surgery

Switching diluent suppliers mid-protocol introduces variables that are difficult to isolate while sourcing from a single manufacturer eliminates that inconsistency

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