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Crowther RR, Qualls JE

To summarize, 2D cell models of cell lines are the easiest to handle and most reproducible models for in vitro toxico-metabolomic studies

Treatment with exogenous GSH also maintained barrier integrity without astrocytes, indicating that increasing GSH levels during disease may enhance BBB functionality (58)

It function in melanin synthesis in the skin and its capacity to stop an enzyme cited before that results in melanin overproduction make it especially helpful

Seven pivotal studies utilizing this model have demonstrated the multifaceted neuroprotective effects of natural products, as detailed below (Table 9)