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Furthermore, preclinical studies have demonstrated synergistic effects when FSEN1 was used alongside endoperoxide-derived ferroptosis inducers, such as dihydroartemisinic acid (101)
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Thus, NAPRT negative tumors are highly dependent on NAMPT activity, making them perfect candidates for treatment with NAMPT inhibitors
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As the viral load increases, the patients immune system weakens, and becomes susceptible to opportunistic infection
