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53,54 However, it has also been suggested that the enhanced release of proinflammatory cytokines (TNF-, IL-1, IL-6, and IL-10) and chemokines (monocyte chemoattractant protein-1, macrophage inflammatory protein-2, and IL-8) further promotes hepatocyte damage, thereby aggravating necrosis
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in cecum perforation (after perforation (Drmic et al., 2018), unlike empty vessels (not visible), blood vessels were filled with blood and were thereby clearly presented as blood vessels running toward the defect, with less bleeding and increased healing)
