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4.1 Heme Synthesis 4.1.1 Glycine The first step and committed step of heme synthesis is the condensation of glycine and succinyl-coA to form ALA

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For example, vincristine, DOX, and etoposide are substrates for P-gp/ABCB1 [147], while methotrexate is a substrate for MRP4 [148], and imatinib, gefitinib, and nilotinib are substrates for BCRP/ABCG2 [149,150]

Livers 49 received a bolus of NAC (200 mg) at the start of perfusion followed by a continuous NAC infusion at a standard rate of 200 mg/hour via a port on the hepatic artery circuit

doi: 10.1186/s12967-023-04116-4 92 GonzlezFSiaCLShepardMKRoteNSMiniumJ