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Current Understanding of the Physiopathology, Diagnosis and Therapeutic Approach to Alzheimer's Disease. Biomedicine 9: 1910

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The Goldie-Coldman model implies a greater chance of cure if therapy is begun early, when only microscopic foci of tumor cells are present, and also predicts a better therapeutic effect when 2 equally effective and non-crossresistant drugs are alternated rather than given sequentially, as this minimizes the emergence of cell populations that are resistant to both drugs