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9, 10 Mechanistic studies have found that the 3-halo-4,5-dihy-droisoxazole scaffold of acivicin can react with cysteine residues in enzymes such as glutamine amidotransferase to form a covalent bond by displacement of the chlorine atom (Figure 1A)

Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen