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Under normal physiological conditions, ROS play an essential role in cellular homeostasis by maintaining biological functions (Jaboska-Trypu et al

Since that time, numerous studies have demonstrated that H 2 has significant therapeutic effects on various diseases, including those related to brain oxidative stress, liver and intestinal transplantation, myocardial injury, and atherosclerosis (Fukuda et al., 2007

Hematoxylin and eosin staining of major organs showed no observable toxicity, confirming systemic safety 19

It has been also observed that expression of AtDJ-1a is induced by various stresses and interacts with several stress inducible proteins such as superoxide dismutase and glutathione peroxidase 21

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