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Tremino, L., Forcada-Nadal, A

It has been shown that serotonin receptors can modulate dopaminergic functions, but their effect may have different tendencies

123,124 Therefore, all the pathways and metabolic reactions in which NAD is involved are also altered by aging, and this decreased metabolic activity has been associated with numerous aging-related metabolic diseases, such as diabetes

While comorbid conditions like long COVID, fibromyalgia (FM), and postural orthostatic tachycardia syndrome (POTS) are common in ME/CFS, the more critical diagnostic complication arises from symptom presentations that resemble pre-malignant states, and undiagnosed rheumatic diseases, neurological diseases and endocrinopathies, increasing the risk of misdiagnosis

Secondly, ketone bodies are metabolized in mitochondria, resulting in less NAD + consumption and an increase in the NAD + /NADH ratio in the cytoplasm (144)