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Pre-existing neutralizing antibodies to AAVrh.10 appear to be less prevalent than those to AAV2 or AAV8, supporting the suitability of AAVrh.10 for liver-directed applications (69)
In animal models of hypertension, cineole has been shown to decrease SBP and increase plasma nitrite levels (Moon et al., 2014)
Disentangling the DNA-binding specificities of individual PIFs in this cooperative context will require genomic assays (e.g., ChIP-seq or CUT&RUN) in thermomorphogenetic conditions, ideally combined with perturbations that selectively disrupt oligomerization interfaces
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