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Activation of MC1R via Gs cAMP MITF (the master transcription factor of melanogenesis) leads to: Activation of tyrosinase , the key enzyme of melanin synthesis Conversion of pheomelanin (red/yellow pigment) to eumelanin (black/brown)

However, this process requires L-carnitine as a carrier to promote the entry of fatty acids into the mitochondria for oxidation and breakdown

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