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Going beyond 500mcg rarely provides additional benefit and may increase the likelihood of mild side effects like headaches or injection site reactions

doi: 10.1016/j.neuroscience.2014.11.018

Topical application offers limited penetration for deep spinal structures

That article reflected the state of a scientific debate that has since been resolved

Whether this approach achieves meaningful olfactory transport versus primarily systemic absorption through the nasal vasculature is genuinely unknown at the level of controlled human research