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Drug metabolic enzyme genotype-phenotype discrepancy: high phenoconversion rate in patients treated with antidepressants

TUDCA has repeatedly shown neuroprotective effects in preclinical models of neurodegeneration and brain injury.39 40 But the only large human trials in ALS have been negative, leaving its role in brain health unproven

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In order to absorb this form of B12, stomach secretions are required to remove the animal protein and release the B12

In addition, protein expression with ALS-associated mutations reduces LLPS and enhances aggregation 52