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Phase 2 body composition data from the Lancet Diabetes and Endocrinology substudy showed retatrutide achieving fat mass reductions of 15.2% at the 4mg dose, 26.1% at 8mg, and 23.2% at 12mg, while the proportion of lean mass loss relative to total weight loss remained comparable to other GLP-1 compounds

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The 12mg group may have had different baseline compositions, or the additional weight loss at 12mg may have included a slightly higher proportion of lean tissue

High homocysteine levels can raise heart disease risk