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For poor circulation, 2 x 500mg servings per day is enough, whereas for blood vessel disorders, or for people looking to increase athletic performance, 1000mg 1500mg twice per day (2000mg 3000mg in total) is recommended
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Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice

Its naturally produced in the body from amino acids like lysine and methionine, and is also found in red meat and dairy