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It was proposed that the deamidation of nitrogen by GLS contributes to the major intracellular pool of glutamate, another NEAA that can continue to supply both nitrogen and carbon for other biosynthetic reactions

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In the next step of the one-carbon cycle, SAM donates its methyl group to a variety of acceptor molecules, leading to S-adenosylhomocysteine (SAH) formation ( Figure 1 ) (Lu, 2013)

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