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The alleviation of THO, as well as the depletion of NK/NKT cells, significantly reduced the presence of activated DCs in the inflamed eyes of DED mice, alleviated their antigen-presenting properties, attenuated Th1 and Th17 cell-driven eye inflammation, down-regulated MMP-3 and MMP-9 expression, and reduced apoptosis of their corneal and conjunctival epithelial cells, confirming the important pathogenic role of THO in NK and NKT cell-driven inflammation in the eyes of DED patients [58]

10 Also, Bersani et al reported moderate-severe AEs in 3 fluoxetine-treated patients