histone modification glutathione Mastering Methylation: Unlocking the Secrets

Wu K, Yan M, Liu T, Wang Z, Duan Y, Xia Y, et al

Regulatory T cells (Tregs) display impaired suppressive function and fail to restrain effector T-cell activity (2016)

Oxidized glutathione (GSSG), produced upon reduction of hydroperoxide by GPX, is recycled to its reduced state by GR and NADPH

They can damage cells by damaging membrane receptor proteins, inactivating proteins required for energy production by the body, and inactivating enzymes required for normal cellular metabolism

specifically, the susceptibility of their red cells to oxidative injury and their reduced hepatic capacity for certain key metabolic processes such as glucuronidation contribute to the severity and frequency of certain intoxications