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134 Liver-kinase-B1 (LKB1), a serine/threonine kinase, is the main kinase for Thr172 phosphorylation during energy stress, 135,136,137 a critical step that increases AMPK activity 100-fold in vitro

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Then, MnOOH is also used as an oxidant to oxidize H 2 O 2 into H 2 O and O 2 under an acidic environment, while MnOOH itself is reduced into Mn 2+