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Additionally, Sal also reduces the levels of serum biochemical markers (serum creatinine, blood urea nitrogen (BUN), and uric acid ( Further, the administration of Sal improves proteinuria, enhances nephrin and podocin expressions, and alleviates renal fibrosis and glomerulosclerosis primarily by inhibiting the -catenin signaling pathway ( Briefly, of the three glycoside natural products described above, AS-IV can improve renal fibrosis through multiple pathways

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2015;10(5) doi: 10.1371/journal.pone.0126561

In hypoxia, the increased expression of the mitochondrial gene might involve the phosphorylation of the AKT signaling pathway, rather than the activation of ERK that is activated in a traumatic neuronal injury through PKC (77)