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The SURMOUNT-1 data showed 75% fat loss and 25% lean mass loss with tirzepatide alone

If you look in any biochemistry bookand you look at the chapter for metabolismyou will find the glycolysis, amino acid cycle and fatty acid cycle which are the tripods of metabolizing all the final components of a fully digested food (carbs, protein, fats)

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Retatrutide is a triple-receptor agonist peptide studied in metabolic research for its simultaneous activation of GLP-1, GIP, and glucagon receptors , making it the most advanced multi-pathway metabolic research compound currently available and representing the next generation beyond dual-receptor peptides like Tirzepatide and Semaglutide