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Time points are mean SEM plasma concentrations, and a zero-inflated linear mixed-effects model was used to compare subjects before and after antibiotic exposure

doi: 10.1016/j.lwt.2018.12.028

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However, another study using the CLP mouse model found that administering choline before and after sepsis initiation reduced serum inflammatory mediators such as TNF- and HMGB1, and improved survival via the 7nAChR-dependent mechanism (250, 251)

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