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69,70 SOD1 is a principal antioxidant enzyme located in the cytosol and the mitochondrial intermembrane space (IMS), where it catalyzes the conversion of superoxide radicals to hydrogen peroxide and oxygen, thereby protecting cells from oxidative stress damage

10.1016/j.biopha.2019.109078 131 MaJ.XiaP.ZhouY.LiuZ.ZhouX.WangJ.et al (2020)

NF-B activation, triggered by ROS-mediated degradation of its inhibitor IB, promotes the transcription of genes involved in inflammation and cell survival and is particularly relevant in renal and hepatic ischemia-reperfusion injury, where inflammatory amplification contributes to tissue damage

63 , e1801049 (2019)

Thibault, K