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There was evidence that mice without efficient expression of SOD2 enzyme resulted in significant epidermal thinning. In humans mitochondrial dysfunction promotes cellular senescence in epidermal keratinocytes in culture. [7] This means because of senescence, there were fewer cells in the epidermis, causing it to be thinner

Briefly, cell samples were collected and homogenized in TRIzol reagent on ice, or tissue samples were snap-frozen in liquid nitrogen and pulverized

The dose of methotrexate was based on literature showing neurotoxicity at 1 M (Bruce-Gregorios et al., 1991)

[DOI] [PubMed] [Google Scholar] Gregorc V

Amelioration of oxidative stress damage by esculetin
