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Velichkovsky BB, Razvaliaeva AY, Khlebnikova AA, Manukyan PA, Kasatkin VN, Barmin AV

L-carnitine sources There are three main sources of L-carnitine in newborns: endogenous synthesis, pre-natal storage, and post-natal exogenous supplementation

Carnitine is found throughout the body including in the heart muscles liver and kidney

Mobitz I: Shortening of PP interval, followed by a PP pause that is less than twice the normal PP interval Mobitz II: Pause is near multiple of the normal PP interval

Several interrelated mechanisms likely underlie this dysregulation, including the hyperglycemic microenvironment, insulin resistance, chronic oxidative stress, and progressive renal structural damage, which collectively impair carnitine homeostasis through multidimensional and cascading pathophysiological mechanisms