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doi:10.1007/s00405-020-05925-9

In animal studies, yes

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And some evidence suggests that a combo of an mRNA vaccine with an adenovirus-based vaccine like J&Js could have some advantages

Previous work has reported relatively increased Firmicutes and Proteobacteria and decreased Bacteroidetes in mice on an HFD, regardless of concomitant obesity (weight gain was minimized using a RELM knockout mouse 78 ) 78,79