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In conditions such as pancreatic ductal adenocarcinoma and heart failure, the effects caused by changes in lactate levels cannot be reversed merely by manipulating P300 [33, 41]

The H 2 O 2 concentration drives the redox balance in the cell from GSH toward GSSG (see Figure 1) and the increased concentrations of H 2 O 2 and GSSG can modulate many enzymes in one-carbon metabolism (see Section E)
While they do not fully replicate the specialized heterogeneity of bone marrow endothelial cells (BMECs), they provide a reproducible platform for investigating core mechanisms relevant to vascular biology in skeletal tissues

Correia, S., Cardoso, H