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5 End nicotinamide adenine dinucleotide cap in human cells promotes RNA decay through DXO-mediated deNADding

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Genetic alterations of the malignant cells of GBM also involve the inactivation of tumor suppressor genes ( PTEN , P16 , RB , and TP53 ) [12,13,14], promoting cell proliferation due to a down-regulation of apoptosis by an increase in the levels of anti-apoptotic proteins (Bcl-2, Mcl-1, Bcl-xL, HIAP-1, HIAP-2, and XIAP) and a decrease in pro-apoptotic proteins (Bid, Bak, Bax, Bad, Bim, PUMA, NOXA, caspases-8, -10, -9, Apaf, DR4, Fas, and FADD) [15,16,17,18,19,20]

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PubChem Reference: View compound profile on NIH PubChem Key Characteristics MOLECULAR PROFILE Formula: C 62 H 98 N 16 O 22 Weight: 1,419.53 g/mol CAS: 137525-51-0 Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val PHYSICAL PROPERTIES Form: White to off-white lyophilized powder Solubility: Readily dissolves in water Stability: Stable across various pH conditions Storage: Keep refrigerated 3646 F (28 C) Related products GHK-Cu $50.00 $90.00Price range: $50.00 through $90.00 CJC-1295 $60.00 $95.00Price range: $60.00 through $95.00