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If supplementation stops entirely, carnitine levels in the blood and tissues will dangerously drop again [13] [7]

In parallel, plasma levels of TMAOmeasured via LC-MS/MSserve as a functional readout of microbial metabolism [15], while circulating microRNAs such as miR-21-5p and miR-126 offer additional insight into host inflammatory and vascular responses [32, 33]

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NIH and Office of Dietary Supplements grants HL103866, HL126827, and DK106000, and the Leducq Foundation

doi: 10.1002/jcp.22054