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However, recent findings indicate that iclepertin did not produce statistically significant cognitive or functional improvements in schizophrenia after 6 months of treatment, despite being safe and tolerated (Rosenbrock et al

The CUT domains of CUX1 have also been shown to stimulate the 5-incision activity of APE1 as well as the dRP-lyase, DNA polymerase, and strand-displacement activities of DNA Pol

In the same study it was shown that the vitamin D receptor was expressed in apical epithelial cells, making it an ideal target for inhaled delivery

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10.1016/j.cell.2012.03.042 35 DixonS