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Highly aggregated molecular complexes have demonstrated different behavior in terms of radical scavenging activity compared to monomers in simple aqueous polar solvents [77]

The test lotion was composed of 2% (weight/weight [w/w]) GSSG (KYOWA HAKKO BIO CO., LTD., Tokyo, Japan), together with other ingredients, including 1,3-butylene glycol, mineral oil, 1,3-pentanediol, cetostearyl alcohol, self-emulsifiable glyceryl monostearate, ethylhexyl palmitate, polyethylene glycol monostearate, 1,3-hexandiol, 2-phenoxyethanol, carboxyvinyl polymer, polyacrylic acid amide, light liquid isoparaffin, polyoxyethylene lauryl ether, fragrance, and water (Table 1)

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22 Therefore, to determine whether the metabolite induces proteotoxicity in part through UPS inhibition, we reduced proteasome function with a range of MG132 concentrations and identified that (at concentrations above 5 M) MG132 induces neurodegeneration in the presence of -synuclein and that this neurotoxicity epistatically regulates metabolite-induced neurotoxicity (Supplementary Figure S4a)