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One explanation for this phenomenon may be attributable to the solubility of VIC, which must be transported across the bloodbrain barrier in an active mode to reach the CNS

[Crossref] DiPirro JM, Kristal MB (2004) Placenta ingestion by rats enhances delta- and kappa-opioid antinociception, but suppresses mu-opioid antinociception

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Because AOD 9604 was engineered to isolate a specific fragment of the HGH molecule, its proposed mechanism and its considerations differ from secretagogues that stimulate the bodys own growth hormone release

However, a small number of GHR antagonists are in clinical trials or preclinical development, and we anticipate that these will eventually expand the options available for clinical and research applications