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Los estudios cientficos, cada vez ms numerosos, requieren de ensayos clnicos bien controlados, que enrolen suficiente nmero de pacientes y sean desarrollados con una metodologa cuidadosa
AGE-R1 exerts a beneficial effect on the development of diabetic kidney disease [13]
doi: 10.1111/j.1743-6109.2008.00945.x
Also, more generally, development of non-glutamate drugs for pain and depression has been plagued by failures in advanced human trials
