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In HFD-induced obese insulin-resistant rats subjected to cardiac ischemiareperfusion injury, dapagliflozin, an SGLT2 inhibitor, exhibited superior cardioprotective efficacy compared with vildagliptin, a DPP-4 inhibitor, as evidenced by suppression of mitochondrial Drp1 expression, reduced infarct size, and improved left ventricular function [199]

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