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Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate

Signaling is typically dose and time dependent

Further analysis of the spleen and bone marrow cells showed a reduced ROS content consistent with a significantly reduced mitochondrial membrane potential and superoxide accumulation and an increase in spontaneous proliferation

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With repeated doses, one patient was able to ambulate and perform activities of daily living without pre-syncopal episodes arising from dyspnea