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A second evaluation within the same year requires documented clinical justification

If [APAP] is below the 150-line, there is no need to treat or gather further data points When time of ingestion is in doubt, use the earliest possible time of ingestion (similar to last known well in stroke care) as this provides the most conservative approach [APAP] prior to 4 hours after ingestion are not helpful and rather may be harmful by skewing management decisions (Seifert 2015)

Additionally, brain glucose metabolism may be controlled by neuronal insulin and its receptor signaling pathways [52]

S2 of the ESM

another when theyre in overall stable health