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First-in-Human trials follow a cautious and progressive dose-escalation approach designed to support continuous safety evaluation throughout the study
Epithelialmesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI
Cerebrovascular disease exacerbates dementia's severity and rate of development even further [55]
Interestingly, GPx4 expression was down-regulated in breast cancer cells compared with normal breast cells [19]
FEBS Lett 589:26612667
