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Chemically, it is a synthetic fragment of Thymosin Beta-4, a protein the body produces naturally

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Instead, pro-inflammatory cytokine production and inflammasome activation in macrophages predominantly relies on the regulation of the Nrf2 response 80 , which can be primarily activated by glutathione or thioredoxin systems, as well as to a lesser extent NOXs 81

Remarkably, the susceptibility to cuprizone, extent of hydrocephalus, spatiotemporal pattern of de- and remyelination or the glial reaction are varying between species, mice strains or simply between different brain regions (Carlton, 1976

These peptides are still being studied for their potential role in human treatment and disease applications