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Once into the brain, Vit B12 interacts with genes (LRRK2), proteins (synuclein and Lewy bodies), neurotransmitters (dopamine, Acetylcholine (Ach)) and metabolites that do impact on CNS hemostasis

Kontogeorgos G, Stefaneanu L, Kovacs K, Cheng Z

Biochem Biophys Res Commun (2003) 311(4):8706
Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia
Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta
